|Application ||WB, E|
|Other Accession||NP_032521.1, 3956, 16852 (mouse), 56646 (rat)|
|Predicted||Human, Pig, Cow|
|Calculated MW||14716 Da|
|Other Names||Galectin-1, Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, LGALS1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||galectin-1 (mouse) Antibody (N-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level) Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells|
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A novel galectin-1 and interleukin 2 receptor beta haplotype is associated with autoimmune myasthenia gravis. PÃ¡l Z, Antal P, Millinghoffer A, HullÃ¡m G, PÃ¡lÃ³czi K, TÃ³th S, Gabius HJ, MolnÃ¡r MJ, Falus A, BuzÃ¡s EI, Journal of neuroimmunology 2010 Aug : . PMID: 20728947
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