|Application ||WB, E|
|Other Accession||NP_963293.1, 57447, 29811 (mouse), 171114 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||40798 Da|
|Other Names||Protein NDRG2, N-myc downstream-regulated gene 2 protein, Protein Syld709613, NDRG2, KIAA1248, SYLD|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDRG2 Antibody (N-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).|
|Tissue Location||Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver Expressed in dendritic cells, but not in other blood cells Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoform a (NP_963293.1) only. Reported variants represent identical protein: NP_963831.1, NP_963293.1, NP_963834.1, NP_963833.1.
Expression of NDRG2 in esophageal squamous cell carcinoma. Shi H, Li N, Li S, Chen C, Wang W, Xu C, Zhang J, Jin H, Zhang H, Zhao H, Song W, Feng Q, Feng X, Shen X, Yao L, Zhao Q, Cancer science 2010 May 101 (5): 1292-9. PMID: 20331630
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