|Application ||IHC, E|
|Other Accession||NP_003404.1, 7547, 22773 (mouse), 367944 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||50569 Da|
|Other Names||Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZIC3 (aa178-189) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to NOT cross-react with other ZIC proteins.
Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain. Hatayama M, Tomizawa T, Sakai-Kato K, Bouvagnet P, Kose S, Imamoto N, Yokoyama S, Utsunomiya-Tate N, Mikoshiba K, Kigawa T, Aruga J, Human molecular genetics 2008 Nov 17 (22): 3459-73. PMID: 18716025
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