|Other Accession||NP_115571.1, NP_620305.1, 6651, 20658 (mouse), 304092 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||263830 Da|
|Other Names||Protein SON, Bax antagonist selected in saccharomyces 1, BASS1, Negative regulatory element-binding protein, NRE-binding protein, Protein DBP-5, SON3, SON, C21orf50, DBP5, KIAA1019, NREBP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SON Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf50, DBP5, KIAA1019, NREBP|
|Function||RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions.|
|Cellular Location||Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2|
|Tissue Location||Widely expressed, with the higher expression seen in leukocyte and heart|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms B ( NP_115571.1) and F (NP_620305.1).
Son is essential for nuclear speckle organization and cell cycle progression. Sharma A, Takata H, Shibahara K, Bubulya A, Bubulya PA, Molecular biology of the cell 2010 Feb 21 (4): 650-63. PMID: 20053686
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