|Application ||WB, E|
|Other Accession||NP_114121.2, NP_001153780.1, 83852, 239122 (mouse)|
|Predicted||Mouse, Pig, Dog, Cow|
|Calculated MW||81894 Da|
|Other Names||Histone-lysine N-methyltransferase SETDB2, 126.96.36.199, Chronic lymphocytic leukemia deletion region gene 8 protein, Lysine N-methyltransferase 1F, SET domain bifurcated 2, SETDB2, C13orf4, CLLD8, KMT1F|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SETDB2 Antibody (C or N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C13orf4, CLLD8, KMT1F|
|Function||Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.|
|Cellular Location||Nucleus. Chromosome|
|Tissue Location||Ubiquitous. Highest expression in heart, testis and ovary|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_114121.2; NP_001153780.1).
CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation. Falandry C, Fourel G, Galy V, Ristriani T, Horard B, Bensimon E, Salles G, Gilson E, Magdinier F, The Journal of biological chemistry 2010 Jun 285 (26): 20234-41. PMID: 20404330
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