|Application ||WB, E|
|Other Accession||NP_001005242.2, NP_004563.2, 5318, 67451 (mouse), 287925 (rat)|
|Predicted||Human, Dog, Cow|
|Calculated MW||97415 Da|
|Other Names||Plakophilin-2, PKP2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Plakophilin 2 (aa125-139) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in junctional plaques.|
|Cellular Location||Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes|
|Tissue Location||Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001005242.2; NP_004563.2).
Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients--disease-causing or innocent bystanders? Christensen AH, Benn M, Tybjaerg-Hansen A, Haunso S, Svendsen JH, Cardiology 2010 115 (2): 148-54. PMID: 19955750
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