|Application ||WB, E|
|Other Accession||NP_055399.1, 30001|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||54393 Da|
|Other Names||ERO1-like protein alpha, ERO1-L, ERO1-L-alpha, 1.8.4.-, Endoplasmic oxidoreductin-1-like protein, Oxidoreductin-1-L-alpha, ERO1L|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERO1-like (aa105-118) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum|
|Tissue Location||Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum|
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Crystal structures of human Ero1? reveal the mechanisms of regulated and targeted oxidation of PDI. Inaba K, Masui S, Iida H, Vavassori S, Sitia R, Suzuki M. EMBO J. 2010 Oct 6;29(19):3330-43. PMID: 20834232
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