|Application ||WB, IHC, E|
|Other Accession||NP_061834.1, NP_001001895.1, 53347|
|Calculated MW||74123 Da|
|Other Names||Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, CLIP4, Suppressor of T-cell receptor signaling 2, STS-2, T-cell ubiquitin ligand 1, TULA-1, UBASH3A, STS2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STS2 / TULA (aa470-482) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_061834.1; NP_001001895.1).
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis
of receptor tyrosine kinases. Kowanetz K, Crosetto N, Haglund K, Schmidt MH, Heldin CH, Dikic I. J Biol Chem. 2004 Jul 30;279(31):32786-95. PMID: 15159412
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