|Application ||WB, E|
|Other Accession||NP_000255.2, NP_001077072.1, NP_001077071.1, NP_001077073.1, 5727, 19206 (mouse), 89830 (rat)|
|Predicted||Human, Rat, Dog, Cow|
|Calculated MW||160545 Da|
|Other Names||Protein patched homolog 1, PTC, PTC1, PTCH1, PTCH|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTCH1 (aa266-280) Antibody (C or N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_000255.2; NP_001077072.1; NP_001077071.1; NP_001077073.1). Reported variants represent identical protein: NP_001077075.1, NP_001077074.1, NP_001077073.1, NP_001077076.1
Detecting tissue-specific alternative splicing and disease-associated aberrant
splicing of the PTCH gene with exon junction microarrays. Nagao K, Togawa N, Fujii K, Uchikawa H, Kohno Y, Yamada M, Miyashita T. Hum Mol Genet. 2005 Nov 15;14(22):3379-88. PMID: 16203740
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