|Application ||WB, E|
|Other Accession||NP_038474.2, NP_001138597.1, 23608, 54484 (mouse)|
|Predicted||Pig, Dog, Cow|
|Calculated MW||53349 Da|
|Other Names||E3 ubiquitin-protein ligase makorin-1, 6.3.2.-, RING finger protein 61, MKRN1, RNF61|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MKRN1 (aa105-118) Antibody (internet regoin) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_038474.2; NP_001138597.1).
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. Kim JH, Park SM, Kang MR, Oh SY, Lee TH, Muller MT, Chung IK. Genes Dev. 2005 Apr 1;19(7):776-81. PMID: 15805468
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