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MKRN1 (aa105-118) Antibody (internet regoin)

Peptide-affinity purified goat antibody

  • WB - MKRN1 (aa105-118) Antibody (internet regoin) AF3533a
    HEK293 lysate (10ug protein in RIPA buffer) over expressing Human MKRN1 with DYKDDDDK tag probed with AF3533a (0.3ug/ml) in Lane A and probed with anti- DYKDDDDK Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AF3533a (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UHC7
Other Accession NP_038474.2, NP_001138597.1, 23608, 54484 (mouse)
Reactivity Human, Mouse
Predicted Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 53349 Da
Additional Information
Gene ID 23608
Other Names E3 ubiquitin-protein ligase makorin-1, 6.3.2.-, RING finger protein 61, MKRN1, RNF61
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMKRN1 (aa105-118) Antibody (internet regoin) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MKRN1
Synonyms RNF61
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This antibody is expected to recognize both reported isoforms (NP_038474.2; NP_001138597.1).


Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. Kim JH, Park SM, Kang MR, Oh SY, Lee TH, Muller MT, Chung IK. Genes Dev. 2005 Apr 1;19(7):776-81. PMID: 15805468

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$ 325.00
Cat# AF3533a
(40 western blots)
Availability: 7-10 days
Bulk Size
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