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APOBEC3D (aa61-74) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - APOBEC3D (aa61-74) Antibody (internal region) AF3537a
    AF3537a (0.3 µg/ml) staining of A549 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96AK3
Other Accession NP_689639.2, 140564
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 46598 Da
Additional Information
Other Names DNA dC->dU-editing enzyme APOBEC-3D, A3D, 3.5.4.-, APOBEC3D
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPOBEC3D (aa61-74) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
Cellular Location Cytoplasm. Cytoplasm, P-body.
Tissue Location Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung
Research Areas
Citations (0)

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APOBEC3B and APOBEC3F inhibit L1 retrotransposition
by a DNA deamination-independent mechanism. Stenglein MD, Harris RS. J Biol Chem. 2006 Jun 23;281(25):16837-41. PMID: 16648136

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$ 325.00
Cat# AF3537a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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