|Application ||WB, E|
|Other Accession||NP_056255.2, 25902, 270685 (mouse), 361472 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||105790 Da|
|Other Names||Monofunctional C1-tetrahydrofolate synthase, mitochondrial, 126.96.36.199, Formyltetrahydrofolate synthetase, MTHFD1L, FTHFSDC1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTHFD1L (aa535-538) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.|
|Tissue Location||Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Parle-McDermott A, Pangilinan F, O'Brien KK, Mills JL, Magee AM, Troendle J, Sutton M, Scott JM, Kirke PN, Molloy AM, Brody LC, Human mutation 2009 Dec 30 (12): 1650-6. PMID: 19777576
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.