|Other Accession||NP_000323.2, 6310, 20238 (mouse), 25049 (rat)|
|Predicted||Human, Mouse, Rat, Pig, Cow|
|Calculated MW||86923 Da|
|Other Names||Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ataxin-1 (aa686-699) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.|
|Cellular Location||Cytoplasm. Nucleus. Note=Colocalizes with USP7 in the nucleus|
|Tissue Location||Widely expressed throughout the body.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001121636.1, NP_000323.2
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776. Duvick L, Barnes J, Ebner B, Agrawal S, Andresen M, Lim J, Giesler GJ, Zoghbi HY, Orr HT, Neuron 2010 Sep 67 (6): 929-35. PMID: 20869591
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