|Application ||WB, IHC, E|
|Other Accession||NP_001127666.1, NP_001090.2, 55|
|Calculated MW||44566 Da|
|Other Names||Prostatic acid phosphatase, PAP, 22.214.171.124, 5'-nucleotidase, 5'-NT, 126.96.36.199, Ecto-5'-nucleotidase, Thiamine monophosphatase, TMPase, PAPf39, ACPP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACPP / PAP (aa269-282) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.|
|Cellular Location||Isoform 1: Secreted|
|Tissue Location||Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001127666.1; NP_001090.2).
Semen-derived amyloid fibrils drastically enhance HIV infection. MÃ¼nch J, RÃ¼cker E, StÃ¤ndker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, GimÃ©nez-Gallego G, SÃ¡nchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F, Cell 2007 Dec 131 (6): 1059-71. PMID: 18083097
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