|Application ||WB, E|
|Other Accession||NP_945320.1, NP_001121.2, NP_945321.1, 166, 14797 (mouse), 29466 (rat)|
|Calculated MW||21970 Da|
|Other Names||Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AES Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.|
|Tissue Location||Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_945320.1; NP_001121.2; NP_945321.1).
Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. Zhang X, Chen HM, Jaramillo E, Wang L, D'Mello SR. J Neurosci Res. 2008 Aug 15;86(11):2423-31. PMID: 18438919
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