- CITATIONS: 1
|Application ||IHC, E|
|Other Accession||NP_000205.1, 182, 16449 (mouse), 29146 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||133799 Da|
|Other Names||Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAG1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells|
Provided below are standard protocols that you may find useful for product applications.
Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer. Shimizu M, Cohen B, Goldvasser P, Berman H, Virtanen C, Reedijk M. Cancer Res. 2011 Jan 1;71(1):277-86. PMID: 21199807
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