|Application ||WB, E|
|Other Accession||NP_057167.2, NP_149421.2, 1268, 12801 (mouse), 25248 (rat)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||52858 Da|
|Other Names||Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CB1 (aa44-58) Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_057167.2; NP_149421.2). Reported variants represent identical protein: NP_001153731.1, NP_001153732.1, NP_057167.2, NP_001153730.1, NP_001153698.1
Binding of the hemopressin peptide to the cannabinoid CB1 receptor:
structural insights. Scrima M, Di Marino S, Grimaldi M, Mastrogiacomo A, Novellino E, Bifulco M,
D'Ursi AM. Biochemistry. 2010 Dec 14;49(49):10449-57. PMID: 21062041
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