|Application ||WB, E|
|Other Accession||NP_057167.2, NP_149421.2, 1268, 12801 (mouse), 25248 (rat)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||52858 Da|
|Other Names||Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CB1 (aa44-58) Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_057167.2; NP_149421.2). Reported variants represent identical protein: NP_001153731.1, NP_001153732.1, NP_057167.2, NP_001153730.1, NP_001153698.1
Binding of the hemopressin peptide to the cannabinoid CB1 receptor:
structural insights. Scrima M, Di Marino S, Grimaldi M, Mastrogiacomo A, Novellino E, Bifulco M,
D'Ursi AM. Biochemistry. 2010 Dec 14;49(49):10449-57. PMID: 21062041
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.