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FUT2 Antibody (internal region, near N-Term)

Peptide-affinity purified goat antibody

     
  • WB - FUT2 Antibody (internal region, near N-Term) AF3568a
    AF3568a (1 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q10981
Other Accession NP_000502.4, 2524
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 39017 Da
Additional Information
Gene ID 2524
Other Names Galactoside 2-alpha-L-fucosyltransferase 2, 2.4.1.69, Alpha(1, 2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, SE2, Secretor blood group alpha-2-fucosyltransferase, Secretor factor, Se, FUT2, SEC2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFUT2 Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FUT2
Synonyms SEC2
Function Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).
Cellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi
Tissue Location Small intestine, colon and lung.
Research Areas
Citations (0)

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Background

Reported variants represent identical protein: NP_001091107.1, NP_000502.4

References

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI; International IBD Ge Hum Mol Genet. 2010 Sep 1;19(17):3468-76. PMID: 20570966

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$ 335.00
Cat# AF3568a
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