|Application ||WB, E|
|Other Accession||NP_000502.4, 2524|
|Calculated MW||39017 Da|
|Other Names||Galactoside 2-alpha-L-fucosyltransferase 2, 184.108.40.206, Alpha(1, 2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, SE2, Secretor blood group alpha-2-fucosyltransferase, Secretor factor, Se, FUT2, SEC2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FUT2 Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi|
|Tissue Location||Small intestine, colon and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001091107.1, NP_000502.4
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI; International IBD Ge Hum Mol Genet. 2010 Sep 1;19(17):3468-76. PMID: 20570966
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