|Application ||WB, E|
|Other Accession||NP_008830.2, NP_777280.1, 3420, 170718 (mouse), 94173 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||42184 Da|
|Other Names||Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, 126.96.36.199, Isocitric dehydrogenase subunit beta, NAD(+)-specific ICDH subunit beta, IDH3B|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IDH3B (aa33-46) Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform a (NP_008830.2) and isoform b (NP_777280.1).
Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. Bzymek KP, Colman RF. Biochemistry. 2007 May 8;46(18):5391-7. PMID: 17432878
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