|Application ||WB, E|
|Other Accession||NP_036211.2, 8694|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||55278 Da|
|Other Names||Diacylglycerol O-acyltransferase 1, 126.96.36.199, ACAT-related gene product 1, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, 188.8.131.52, Diglyceride acyltransferase, DGAT1, AGRP1, DGAT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DGAT1 (aa67-79) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Efficient hepatitis C virus particle formation requires
diacylglycerol acyltransferase-1. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR,
Farese RV Jr, Ott M. Nat Med. 2010 Nov;16(11):1295-8. PMID: 20935628
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