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HTR1A (aa249-262) Antibody (internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08908
Other Accession NP_000515.2, 3350
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 46107 Da
Additional Information
Gene ID 3350
Other Names 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, G-21, Serotonin receptor 1A, HTR1A, ADRB2RL1, ADRBRL1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHTR1A (aa249-262) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTR1A
Synonyms ADRB2RL1, ADRBRL1
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells
Research Areas
Citations (0)

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The HTR1A and HTR1B receptor genes influence stress-related information
processing. Mekli K, Payton A, Miyajima F, Platt H, Thomas E, Downey D, Lloyd Williams K, Chase D, Toth ZG, Elliott R, Ollier WE, Anderson IM, Deakin JF, Bagdy G, Juhasz G. Eur Neuropsychopharmacol. 2011 Jan;21(1):129-39. PMID: 20638825

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$ 325.00
Cat# AF3580a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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