|Other Accession||NP_000515.2, 3350|
|Calculated MW||46107 Da|
|Other Names||5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, G-21, Serotonin receptor 1A, HTR1A, ADRB2RL1, ADRBRL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HTR1A (aa249-262) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells|
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Provided below are standard protocols that you may find useful for product applications.
The HTR1A and HTR1B receptor genes influence stress-related information
processing. Mekli K, Payton A, Miyajima F, Platt H, Thomas E, Downey D, Lloyd Williams K, Chase D, Toth ZG, Elliott R, Ollier WE, Anderson IM, Deakin JF, Bagdy G, Juhasz G. Eur Neuropsychopharmacol. 2011 Jan;21(1):129-39. PMID: 20638825
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