CCP4 (aa748-761) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q96MI9 |
Other Accession | NP_689549.2, 123624, 244071 (mouse), 308724 (rat) |
Predicted | Human, Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 125330 Da |
Gene ID | 123624 |
---|---|
Other Names | Cytosolic carboxypeptidase 4, 3.4.17.-, ATP/GTP-binding protein-like 1, AGBL1, CCP4 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CCP4 (aa748-761) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AGBL1 (HGNC:26504) |
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Function | Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. |
Cellular Location | Cytoplasm, cytosol. |
Tissue Location | Expressed in corneal endothelium. |
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Provided below are standard protocols that you may find useful for product applications.
References
A family of protein-deglutamylating enzymes associated with
neurodegeneration. Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Grau MB, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C. Cell. 2010 Nov 12;143(4):564-78. PMID: 21074048
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