|Application ||WB, E|
|Other Accession||NP_006155.2, NP_001138884.1, NP_001138885.1, 4780, 18024 (mouse), 83619 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||67827 Da|
|Other Names||Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2, NRF2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NRF2 (aa445-458) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents|
|Tissue Location||Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_006155.2; NP_001138884.1; NP_001138885.1).
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Genes Dev. 1999 Jan 1;13(1):76-86. PMID: 9887101
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