|Application ||WB, E|
|Other Accession||NP_003465.3, NP_067673.2, 8038, 11489 (mouse), 679837 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||99542 Da|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, 3.4.24.-, Meltrin-alpha, ADAM12, MLTN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAM12 (aa225-239) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_003465.3; NP_067673.2).
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression. Ray BK, Dhar S, Shakya A, Ray A. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):103-8. PMID: 21173277
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