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DUOX1 (aa972-985) Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - DUOX1 (aa972-985) Antibody (internal region) AF3616a
    AF3616a (0.1 µg/ml) staining of Human Testis lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NRD9
Other Accession NP_059130.2, 53905
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 177235 Da
Additional Information
Gene ID 53905
Other Names Dual oxidase 1, 1.11.1.-, 1.6.3.1, Large NOX 1, Long NOX 1, NADPH thyroid oxidase 1, Thyroid oxidase 1, DUOX1, DUOX, LNOX1, THOX1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUOX1 (aa972-985) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUOX1
Synonyms DUOX, LNOX1, THOX1
Function Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Cellular Location Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells
Tissue Location Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
Research Areas
Citations (0)
citation

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Background

Reported variants represent identical protein: NP_787954.1, NP_059130.2. This antibody is not expected to cross-react with DUOX2.

References

Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R. FEBS Lett. 2005 Aug 29;579(21):4911-7. PMID: 16111680

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$ 341.00
Cat# AF3616a
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