|Application ||WB, E|
|Other Accession||NP_734465.2, 219699, 107449 (mouse), 60630 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||103638 Da|
|Other Names||Netrin receptor UNC5B, Protein unc-5 homolog 2, Protein unc-5 homolog B, p53-regulated receptor for death and life protein 1, UNC5B, P53RDL1, UNC5H2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNC5B (aa629-643) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.|
|Cellular Location||Membrane; Single-pass type I membrane protein Note=Associated with lipid raft|
|Tissue Location||Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Tang X, Jang SW, Okada M, Chan CB, Feng Y, Liu Y, Luo SW, Hong Y, Rama N, Xiong WC, Mehlen P, Ye K. Nat Cell Biol. 2008 Jun;10(6):698-706. PMID: 18469807
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