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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Trib1 (mouse) (aa304-317) Antibody (internal region)
Trib1 (mouse) (aa304-317) Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | Q96RU8 |
| Other Accession | NP_653132.1, 10221, 211770 (mouse), 78969 (rat) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 41009 Da |
| Gene ID | 10221 |
|---|---|
| Other Names | Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, GIG-2, SKIP1, TRIB1 (HGNC:16891) |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Trib1 (mouse) (aa304-317) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIB1 (HGNC:16891) |
|---|---|
| Function | Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1- binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). |
| Tissue Location | Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis. Yokoyama T, Kanno Y, Yamazaki Y, Takahara T, Miyata S, Nakamura T, Blood 2010 Oct 116 (15): 2768-75. PMID: 20610816
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$ 341.00
Cat# AF3622a
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