NaV1.7 (aa1874-1887) Antibody (internal region, near C-Term)
Peptide-affinity purified goat antibody
|Other Accession||NP_002968.1, 6335, 20274 (mouse), 78956 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||226372 Da|
|Other Names||Sodium channel protein type 9 subunit alpha, Neuroendocrine sodium channel, hNE-Na, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, SCN9A, NENA|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NaV1.7 (aa1874-1887) Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Note=In neurite terminals.|
|Tissue Location||Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system Isoform 2 is expressed preferentially in the dorsal root ganglion|
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Provided below are standard protocols that you may find useful for product applications.
Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Cox JJ, Sheynin J, Shorer Z, Reimann F, Nicholas AK, Zubovic L, Baralle M, Wraige E, Manor E, Levy J, Woods CG, Parvari R. Hum Mutat. 2010 Sep;31(9):E1670-86. PMID: 20635406
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