|Application ||WB, E|
|Other Accession||NP_000360.2, NP_001018046.1, 7253|
|Calculated MW||86830 Da|
|Other Names||Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSHR (aa101-115) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the thyroid.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoform 1 (NP_000360.2) and isoform 2 (NP_001018046.1). The immunizing peptide sequence corresponds to a part of the extracellular domain.
Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased
constitutive activity. Nishihara E, Chen CR, Higashiyama T, Mizutori-Sasai Y, Ito M, Kubota S, Amino N, Miyauchi A, Rapoport B. Thyroid. 2010 Nov;20(11):1307-14. PMID: 20929407
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