|Other Accession||NP_003577.2, 8448, 13446 (mouse), 65031 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||43959 Da|
|Other Names||Double C2-like domain-containing protein alpha, Doc2, Doc2-alpha, DOC2A|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DOC2A (aa233-246) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.|
|Cellular Location||Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles|
|Tissue Location||Predominantly expressed in brain. Also expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A, Sasaki T. J Immunol. 2008 Apr 1;180(7):4774-84. PMID: 18354201
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