|Other Accession||NP_598665.2, 100705 (mouse), 116719 (rat)|
|Predicted||Mouse, Rat, Pig|
|Calculated MW||276541 Da|
|Other Names||Acetyl-CoA carboxylase 2, 22.214.171.124, ACC-beta, Biotin carboxylase, 126.96.36.199, ACACB, ACC2, ACCB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACACB (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).|
|Cellular Location||Mitochondrion. Nucleus. Endomembrane system Note=May associate with membranes|
|Tissue Location||Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759).|
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Provided below are standard protocols that you may find useful for product applications.
ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat. Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McMonagle J, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Kiec-Wilk B, Riserus U, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. J Lipid Res. 2010 Dec;51(12):3500-7. PMID: 20855566
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