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SYNGAP1 (aa1169-1183) Antibody (internal region, near C-Term)
Peptide-affinity purified goat antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96PV0 |
| Other Accession | NP_006763.2, 8831, 240057 (mouse), 192117 (rat) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 148284 Da |
| Gene ID | 8831 |
|---|---|
| Other Names | Ras/Rap GTPase-activating protein SynGAP, Neuronal RasGAP, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, SYNGAP1, KIAA1938 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYNGAP1 (aa1169-1183) Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYNGAP1 |
|---|---|
| Synonyms | KIAA1938 |
| Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
References
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Rumbaugh G, Adams JP, Kim JH, Huganir RL. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4344-51. 16537406
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