|Application ||WB, E|
|Other Accession||NP_006763.2, 8831, 240057 (mouse), 192117 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||148284 Da|
|Other Names||Ras/Rap GTPase-activating protein SynGAP, Neuronal RasGAP, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, SYNGAP1, KIAA1938|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYNGAP1 (aa60-72) Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Rumbaugh G, Adams JP, Kim JH, Huganir RL. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4344-51. 16537406
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