|Application ||WB, IHC, E|
|Other Accession||NP_006163.1, 4878, 230899 (mouse), 24602 (rat)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Dog, Cow|
|Calculated MW||16708 Da|
|Other Names||Natriuretic peptides A, CDD-ANF, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, Prepronatriodilatin, Atrial natriuretic factor, ANF, Atrial natriuretic peptide, ANP, NPPA, ANP, PND|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Atrial natriuretic factor Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.|
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Provided below are standard protocols that you may find useful for product applications.
The immunizing peptide represents aa137-150 of the precursor NPPA.
Decompensated heart failure is associated with reduced corin levels and decreased cleavage of pro-atrial natriuretic peptide. Ibebuogu UN, Gladysheva IP, Houng AK, Reed GL. Circ Heart Fail. 2011 Mar 1;4(2):114-20. PMID: 21216831
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