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ULK3 (aa445-458) Antibody (C-Term)

Peptide-affinity purified goat antibody

  • WB - ULK3 (aa445-458) Antibody (C-Term) AF3654a
    AF3654a (1 µg/ml) staining of Human Hippocampus lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6PHR2
Other Accession NP_001092906.1, 25989
Reactivity Human
Predicted Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 53444 Da
Additional Information
Gene ID 25989
Other Names Serine/threonine-protein kinase ULK3,, Unc-51-like kinase 3, ULK3
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsULK3 (aa445-458) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ULK3
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Cellular Location Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
Tissue Location Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord
Research Areas
Citations (0)

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Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. Maloverjan A, Piirsoo M, Kasak L, Peil L, Østerlund T, Kogerman P. J Biol Chem. 2010 Sep 24;285(39):30079-90. PMID: 20643644

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$ 325.00
Cat# AF3654a
(40 western blots)
Availability: 7-10 days
Bulk Size
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