|Application ||WB, E|
|Other Accession||NP_005134.1, NP_001119574.1, 3240|
|Calculated MW||45205 Da|
|Other Names||Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HP alpha chain Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_005134.1; NP_001119574.1).
Haptoglobin phenotype in women with preeclampsia. Sammour RN, Nakhoul FM, Levy AP, Miller-Lotan R, Nakhoul N, Awad HR, Gonen R, Ohel G. Endocrine. 2010 Oct;38(2):303-8. PMID: 20972727
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