CHIT1 (aa409-423) Antibody (internal region, near C Terminus)
Peptide-affinity purified goat antibody
|Application ||WB, E|
|Other Accession||NP_003456.1, 1118|
|Calculated MW||51681 Da|
|Other Names||Chitotriosidase-1, 188.8.131.52, Chitinase-1, CHIT1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHIT1 (aa409-423) Antibody (internal region, near C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.|
|Cellular Location||Secreted. Lysosome. Note=A small proportion is lysosomal|
|Tissue Location||Detected in spleen. Secreted by cultured macrophages.|
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Provided below are standard protocols that you may find useful for product applications.
Reduction in imiglucerase dosage causes immediate rise of chitotriosidase activity in patients with Gaucher disease. Chien YH, Lee NC, Tsai FJ, Chao MC, Hwu WL. Mol Genet Metab. 2010 Sep;101(1):90-1. PMID: 20580583
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