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C16orf57 (aa154-167) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BQ65 |
| Other Accession | NP_078874.2, NP_001182231.1, 79650 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 30268 Da |
| Gene ID | 79650 |
|---|---|
| Other Names | U6 snRNA phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_03040}, hUsb1, 3.1.4.- {ECO:0000255|HAMAP-Rule:MF_03040}, USB1 {ECO:0000255|HAMAP-Rule:MF_03040}, C16orf57 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C16orf57 (aa154-167) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | USB1 {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000312|HGNC:HGNC:25792} |
|---|---|
| Function | 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367). |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23022480} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_078874.2; NP_001182231.1).
References
Mutations in C16orf57 and normal-length telomeres unify a subset of patients with dyskeratosis congenita, poikiloderma with neutropenia and Rothmund-Thomson syndrome. Walne AJ, Vulliamy T, Beswick R, Kirwan M, Dokal I. Hum Mol Genet. 2010 Nov 15;19(22):4453-61. PMID: 20817924
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