SLC1A7 / EAAT5 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | O00341 |
Other Accession | NP_006662.3, 6512, 242607 (mouse) |
Predicted | Human, Mouse, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 60658 Da |
Gene ID | 6512 |
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Other Names | Excitatory amino acid transporter 5, Retinal glutamate transporter, Solute carrier family 1 member 7, SLC1A7, EAAT5 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC1A7 / EAAT5 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC1A7 (HGNC:10945) |
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Synonyms | EAAT5 |
Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D- aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:9108121). Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina (By similarity). |
Cellular Location | Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:Q8JZR4}; Multi-pass membrane protein. Synaptic cell membrane {ECO:0000250|UniProtKB:Q8JZR4}; Multi-pass membrane protein. Note=Located in both cone and rod photoreceptor terminals and in axon terminals of rod bipolar cells. {ECO:0000250|UniProtKB:Q8JZR4} |
Tissue Location | Expressed primarily in retina. Detectable in liver, heart, muscle and brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Regulation of the excitatory amino acid transporter EAAT5 by the serum
and glucocorticoid dependent kinases SGK1 and SGK3. Boehmer C, Rajamanickam J, Schniepp R, Kohler K, Wulff P, Kuhl D, Palmada M, Lang F. Biochem Biophys Res Commun. 2005 Apr 8;329(2):738-42. PMID: 15737648
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