|Application ||WB, E|
|Other Accession||NP_001036.1, 6532, 15567 (mouse), 25553 (rat)|
|Predicted||Human, Rat, Cow|
|Calculated MW||70325 Da|
|Other Names||Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4, HTT, SERT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC6A4 (aa605-618) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin|
|Tissue Location||Expressed in platelets (at protein level).|
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Role of mother's genes and environment in postpartum depression. Mitchell C, Notterman D, Brooks-Gunn J, Hobcraft J, Garfinkel I, Jaeger K, Kotenko I, McLanahan S. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8189-93. PMID: 21576482
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