|Application ||WB, E|
|Other Accession||NP_000778.3, 1621, 13166 (mouse), 25699 (rat)|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||69065 Da|
|Other Names||Dopamine beta-hydroxylase, 220.127.116.11, Dopamine beta-monooxygenase, Soluble dopamine beta-hydroxylase, DBH|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DBH (aa437-448) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conversion of dopamine to noradrenaline.|
|Cellular Location||Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen Secreted|
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Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase. Kim CH, Leung A, Huh YH, Yang E, Kim DJ, Leblanc P, Ryu H, Kim K, Kim DW, Garland EM, Raj SR, Biaggioni I, Robertson D, Kim KS. J Biol Chem. 2011 Mar 18;286(11):9196-204. Epub 2011 Jan 5. PMID: 21209083
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