|Application ||WB, E|
|Other Accession||NP_002451.2, 3662|
|Calculated MW||51772 Da|
|Other Names||Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IRF4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).|
|Tissue Location||Lymphoid cells.|
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C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells. Pal R, Janz M, Galson DL, Gries M, Li S, JÃ¶hrens K, Anagnostopoulos I, DÃ¶rken B, Mapara MY, Borghesi L, Kardava L, Roodman GD, Milcarek C, Lentzsch S, Blood 2009 Oct 114 (18): 3890-8. PMID: 19717648
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