|Application ||WB, E|
|Other Accession||NP_034039.1, 3579|
|Calculated MW||40759 Da|
|Other Names||C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, CDw128b, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B, IL-8 receptor type 2, CD182, CXCR2, IL8RB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD128 / Cxcr2 (mouse) Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Reported isoforms represent identical protein: NP_001548.1, NP_001161770.1. The immunizing peptide represent part of an extracellular domain.
CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK, British journal of cancer 2009 May 100 (10): 1638-46. PMID: 19401689
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