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TRIM6 (aa118-131) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9C030 |
| Other Accession | NP_001003818.1, NP_477514.1, 117854, 445372 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 56400 Da |
| Gene ID | 117854 |
|---|---|
| Other Names | Tripartite motif-containing protein 6, RING finger protein 89, TRIM6, RNF89 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM6 (aa118-131) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM6 |
|---|---|
| Synonyms | RNF89 |
| Function | E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys- 48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response (PubMed:35263596). |
| Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize reported isoforms 1 and 2 (NP_001003818.1; NP_477514.1). Reported variants represent identical protein: NP_001185573.1, NP_001185574.1
References
The tripartite motif family identifies cell compartments. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A. EMBO J. 2001 May 1;20(9):2140-51. PMID: 11331580
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