TBP /Transcription factor IID (aa39-50) Antibody (internal region)
Peptide-affinity purified goat antibody
|Application ||WB, E|
|Other Accession||NP_003185.1, NP_001165556.1, 6908, 21374 (mouse), 117526 (rat)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Dog, Cow|
|Calculated MW||37698 Da|
|Other Names||TATA-box-binding protein, TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit, TBP, GTF2D1, TF2D, TFIID|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBP /Transcription factor IID (aa39-50) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GTF2D1, TF2D, TFIID|
|Function||General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.|
|Tissue Location||Widely expressed, with levels highest in the testis and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_003185.1; NP_001165556.1).
TATA-binding protein in neurodegenerative disease. van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. Neuroscience. 2005;133(4):863-72. PMID: 15916858
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