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ERCC6 (aa717-731) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - ERCC6 (aa717-731) Antibody (internal region) AF3735a
    AF3735a (0.3 µg/ml) staining of HeLa nuclear lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q03468
Other Accession NP_000115.1, 2074, 319955 (mouse), 306274 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 168416 Da
Additional Information
Gene ID 2074
Other Names DNA excision repair protein ERCC-6, 3.6.4.-, ATP-dependent helicase ERCC6, Cockayne syndrome protein CSB, ERCC6, CSB
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsERCC6 (aa717-731) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERCC6
Synonyms CSB
Function Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Maternal origin of a de novo microdeletion spanning the ERCC6 gene in a classic form of the Cockayne syndrome. Zhang H, Gao J, Ye J, Gong Z, Gu X. Eur J Med
Genet. 2011 Jul-Aug;54(4):e389-93. PMID: 21477668

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$ 325.00
Cat# AF3735a
(40 western blots)
Availability: 7-10 days
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