|Application ||WB, E|
|Other Accession||NP_000115.1, 2074, 319955 (mouse), 306274 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||168416 Da|
|Other Names||DNA excision repair protein ERCC-6, 3.6.4.-, ATP-dependent helicase ERCC6, Cockayne syndrome protein CSB, ERCC6, CSB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERCC6 (aa717-731) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions.|
|Tissue Location||Expressed in heart, ovary, but not in granulosa cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Maternal origin of a de novo microdeletion spanning the ERCC6 gene in a classic form of the Cockayne syndrome. Zhang H, Gao J, Ye J, Gong Z, Gu X. Eur J Med
Genet. 2011 Jul-Aug;54(4):e389-93. PMID: 21477668
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