|Application ||WB, E|
|Other Accession||NP_000115.1, 2074, 319955 (mouse), 306274 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||168416 Da|
|Other Names||DNA excision repair protein ERCC-6, 3.6.4.-, ATP-dependent helicase ERCC6, Cockayne syndrome protein CSB, ERCC6, CSB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERCC6 (aa717-731) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions.|
|Tissue Location||Expressed in heart, ovary, but not in granulosa cells.|
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Provided below are standard protocols that you may find useful for product applications.
Maternal origin of a de novo microdeletion spanning the ERCC6 gene in a classic form of the Cockayne syndrome. Zhang H, Gao J, Ye J, Gong Z, Gu X. Eur J Med
Genet. 2011 Jul-Aug;54(4):e389-93. PMID: 21477668
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