|Other Accession||NP_660095.1, NP_001027568.1, NP_071763.2, 64219|
|Calculated MW||71002 Da|
|Other Names||E3 ubiquitin-protein ligase Praja-1, Praja1, 6.3.2.-, RING finger protein 70, PJA1, RNF70|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Praja-1 / RNF70 (aa285-298) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.|
|Tissue Location||Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_660095.1; NP_001027568.1; NP_071763.2).
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. Zoabi M, Sadeh R, de Bie P, Marquez VE, Ciechanover A. Biochem Biophys Res Commun. 2011 May 13;408(3):393-8. PMID: 21513699
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