|Application ||WB, E|
|Other Accession||NP_057667.1, 51297|
|Calculated MW||26713 Da|
|Other Names||BPI fold-containing family A member 1, Lung-specific protein X, Nasopharyngeal carcinoma-related protein, Palate lung and nasal epithelium clone protein, Secretory protein in upper respiratory tracts, Short PLUNC1, SPLUNC1, Tracheal epithelium-enriched protein, Von Ebner protein Hl, BPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BPIFA1 / PLUNC Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LUNX, NASG, PLUNC, SPLUNC1, SPURT|
|Function||Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.|
|Cellular Location||Secreted. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum|
|Tissue Location||Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_057667.1, NP_001230122.1, NP_570913.1
Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP. J Immunol. 2011 Jul 1;187(1):382-90. PMID: 21632717
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