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DYRK1A Antibody (N-Term)

Peptide-affinity purified goat antibody

     
  • WB - DYRK1A Antibody (N-Term) AF3754a
    AF3754a (0.5 µg/ml) staining of K562 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13627
Other Accession NP_001387.2, NP_569120.1, NP_567824.1, NP_569122.1, 1859, 13548 (mouse), 25255 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 85584 Da
Additional Information
Gene ID 1859
Other Names Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 2.7.12.1, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDYRK1A Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DYRK1A
Synonyms DYRK, MNB, MNBH
Function May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.
Cellular Location Nucleus speckle.
Tissue Location Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Research Areas
Citations (0)

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Background

This antibody is expected to recognize all reported isoforms (NP_001387.2; NP_569120.1; NP_567824.1; NP_569122.1). This antibody is not expected to cross-react with DYRK1B.

References

DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Miyata Y, Nishida E. Biochim Biophys Acta. 2011 Oct;1813(10):1728-39. PMID: 21777625

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$ 335.00
Cat# AF3754a
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