|Application ||WB, E|
|Other Accession||NP_001387.2, NP_569120.1, NP_567824.1, NP_569122.1, 1859, 13548 (mouse), 25255 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||85584 Da|
|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 18.104.22.168, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DYRK1A Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DYRK, MNB, MNBH|
|Function||May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.|
|Cellular Location||Nucleus speckle.|
|Tissue Location||Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_001387.2; NP_569120.1; NP_567824.1; NP_569122.1). This antibody is not expected to cross-react with DYRK1B.
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Miyata Y, Nishida E. Biochim Biophys Acta. 2011 Oct;1813(10):1728-39. PMID: 21777625
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