|Application ||WB, E|
|Other Accession||NP_001387.2, NP_569120.1, NP_567824.1, NP_569122.1, 1859, 13548 (mouse), 25255 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||85584 Da|
|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 18.104.22.168, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DYRK1A Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DYRK, MNB, MNBH|
|Function||May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.|
|Cellular Location||Nucleus speckle.|
|Tissue Location||Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_001387.2; NP_569120.1; NP_567824.1; NP_569122.1). This antibody is not expected to cross-react with DYRK1B.
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Miyata Y, Nishida E. Biochim Biophys Acta. 2011 Oct;1813(10):1728-39. PMID: 21777625
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.