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USP6 (aa142-155) Antibody (internal region, near N-Term)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35125
Other Accession NP_004496.2, 9098, 237898 (mouse)
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 158658 Da
Additional Information
Gene ID 9098
Other Names Ubiquitin carboxyl-terminal hydrolase 6,, Deubiquitinating enzyme 6, Proto-oncogene TRE-2, Ubiquitin thioesterase 6, Ubiquitin-specific-processing protease 6, USP6, HRP1, TRE2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUSP6 (aa142-155) Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP6
Synonyms HRP1, TRE2
Function Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Cellular Location Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton
Tissue Location Testis specific. Expressed in various cancer cell lines.
Research Areas
Citations (0)

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This antibody is expected NOT to cross react to USP32 or to the TBC1D3 proteins.


TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Ye Y, Pringle LM, Lau AW, Riquelme DN, Wang H, Jiang T, Lev D, Welman A, Blobel GA, Oliveira AM, Chou MM. Oncogene. 2010 Jun 24;29(25):3619-29. PMID: 20418905

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$ 325.00
Cat# AF3760a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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